Prof. dr. Weber is founder of the ALS clinic in St. Gallen in 2006 and the ALS clinic at the University Hospital Basel and acting chief of all ALS research projects in St. Gallen and Basel.

He is a clinical researcher who has been involved in numerous ALS clinical trials as PI and advisory board member and has published numerous articles on ALS and neuromuscular diseases. The ALS clinic St.Gallen is part of an extensive European network of ALS research participating in several EU-funded projects. Markus is currently a member of the Executive committee of the European network for the cure of ALS (ENCALS).