Dr. Brylev is founder of the ALS Centre Moscow  as from 2011 and provides medical service to ALS patients at Neurology Department at Bujanov Moscow Clinical Hospital with his team.

He is a clinical researcher who has been involved as PI in different ALS investigational projects. He performs his works in the area of protease activity in CSF and serum of ALS patients. In collaboration with the Research Center of Neurology he participated in a gene therapy trial in ALS patients.  Dr. Brylev and his team collaborate with Massachusetts General Hospital and the Anglia Ruskin University in various scientific projects.