Pamela Shaw is a clinician scientist in Neurology and formerly a Wellcome Senior Clinical Fellow. Since 1991 she has led a multidisciplinary programme encompassing laboratory, clinical and symptom management research. In 2000 she was appointed as Professor of Neurology & Head of Neuroscience, University of Sheffield and Consultant Neurologist, Royal Hallamshire Hospital, where she established the Sheffield Care and Research Centre for Motor Neurone Disorders. She is Associate Director and Chair of the MND Clinical Studies Group for the UK Dementia and Neurodegenerative Diseases Clinical Research Network (DeNDRoN) and Academic Director of the Neuroscience Directorate at the Royal Hallamshire Hospital. She has received numerous awards and, most recently receiving the honour of Dame Commander of the Order of the British Empire (DBE) for services to neuroscience.