Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

McLaughlin RL, et al., Nature Communications, 2017

We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological […]

Read more

Detection of long repeat expansions from PCR-free whole-genome sequence data

Dolzhenko E, et al., Genome Res., 2017

Identifying large expansions of short tandem repeats (STRs) such as those that cause amyotrophic lateral sclerosis (ALS) and fragile X […]

Read more

Project MinE: study design and pilot analyses of a large-scale whole-genome sequencing study in amyotrophic lateral sclerosis

W. van Rheenen et al., European Journal of Human Genetics, 2018

The most recent genome-wide association study in amyotrophic lateral sclerosis (ALS) demonstrates a disproportionate contribution from low-frequency variants to genetic […]

Read more

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis

K. Kenna et al., Nature Genetics, 2016

To identify genetic factors contributing to amyotrophic lateral sclerosis (ALS), we conducted whole-exome analyses of 1,022 index familial ALS (FALS) […]

Read more

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

W. van Rheenen et al., Nature Genetics, 2016

To elucidate the genetic architecture of amyotrophic lateral sclerosis (ALS) and find associated loci, we assembled a custom imputation reference […]

Read more Download